Agios Pharmaceuticals

AGIO

Biotechnology · Healthcare

Price

$39.61

+0.89 (+2.30%)

Market Cap

$2.36B

Exchange

NASDAQ

Winston Score

Winston is serious

Below-average fundamentals — multiple weak pillars.

Share count falling — buybacks

−4.1% over 4y

The company has reduced its share count over this period, returning value to shareholders through buybacks.

Diluted shares outstanding: 60.4M (2021) → 58.0M (2025)

Agios Pharmaceuticals, Inc., a biopharmaceutical company, engages in the discovery and development of medicines in the field of cellular metabolism and adjacent areas of biology. The company offers PYRUKYND (mitapivat) an activator of both wild-type and a variety of mutant pyruvate kinase, PK, enzymes for the treatment of hemolytic anemias; and AG-946 that is in Phase I clinical study for treating hemolytic anemias and other indications. Agios Pharmaceuticals, Inc. was incorporated in 2007 and i

Winston Score History

Politician Trades

2 trades / 12mo

2 Congressional buys and 0 sells on AGIO in the last 12 months.

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Growth Profile

For growth stock investors

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+137.7% YoY

YoY Growth Rate

Revenue accelerating

EPS Growth

-9.0% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$334M/ year

↑ Rising (+11% vs prior year)

618.9% of revenue

34.4x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

6.4%ownership

→ Flat

Insiders holding steady — not selling despite ability to

Cash Runway

~3 months

$114M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Short runway — potential dilution ahead through share issuance

Revenue accelerating

Agios Pharmaceuticals grew revenue 138% year-over-year and the growth rate is speeding up. That's the kind of momentum growth investors look for — the question is whether margins can follow.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

Each metric is explained in plain language so you know exactly what you're looking at. Start your free trial now.

Quality

Gross Margin

87.1%

Premium pricing power — 87.1% gross margin

Operating Margin

-530.3%

Losing money on operations — -530.3%

ROCE

-9.8%

Weak — -9.8% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales YoY

+78.3%

Fast-growing sales (78.3% YoY)

EPS YoY

-161.9%

Earnings shrinking (-161.9% YoY)

Earnings per share down more than 10%. Either a bad year, or a real decline.

EPS Consistency

0/8 quarters

Earnings rarely grow — volatile business

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Cash Flow

Cash Conversion

N/A

Data not available

FCF Margin

-582.5%

Burning cash (-582.5%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity

0.02

Conservative — low debt load (0.02)

Interest Cover

N/A

—

Data not available

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Valuation

P/E Ratio (TTM)

N/M

Negative earnings — P/E not meaningful

P/E vs Forward

N/A

not available

Data not available

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Dividends

Not applicable for this business.

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