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Crescent Biopharma

CBIO
27
Biotechnology · Healthcare
Price
$14.75
-0.36 (-2.38%)
Market Cap
$406.7M
Exchange
NASDAQ
Winston Score
27
Winston is worried
Below-average fundamentals — multiple weak pillars.

Share count falling — buybacks

79.8% over 4y

The company has reduced its share count over this period, returning value to shareholders through buybacks.

Diluted shares outstanding: 51.5M (2021) → 10.4M (2025)

Crescent Biopharma is a small biotechnology company focused on developing cancer treatments. It works on drugs that help the immune system fight tumors, a field called oncology. The company does not yet sell approved products and is still in the early stages of clinical research.

Crescent Biopharma makes no meaningful revenue today, which explains its deeply negative operating margin. It funds operations through equity raises and relies entirely on future drug approvals to generate sales. The company operates primarily in the United States and competes in a crowded oncology drug development space against much larger pharmaceutical companies with more resources. The central risk is straightforward: if its drug candidates fail in clinical trials or cannot win regulatory approval, the company may struggle to survive without raising additional capital, which can dilute existing shareholders.

Winston Score History

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

Revenue data limited

EPS Growth

+10.3% YoY

YoY Growth Rate

Steady EPS growth

R&D Spend

$138M/ year

Rising (+392% vs prior year)

>1,000% of revenue

70.7x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

22.7%ownership

Rising

Insiders increasing their stake — aligned with shareholders

Cash Runway

~5 years

$189M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

$189M cash & investments at current burn rate

Heavy R&D investment

Crescent Biopharma is putting 1273% of revenue into R&D and that number is rising. That's 70.7x the sector average. With 5+ years of cash runway, they have time to let it pay off.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Gross Margin
100.0%
Premium pricing power — 100.0% gross margin
Operating Margin
-2380.1%
Losing money on operations — -2380.1%
ROCE
-13.3%
Weak — -13.3% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales YoY
N/A
Data not available
EPS YoY
N/A
Data not available
EPS Consistency
0/8 quarters
Earnings rarely grow — volatile business

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Cash Flow

Cash Conversion
N/A
Data not available
FCF Margin
-1249.1%
Burning cash (-1249.1%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity
0.01
Conservative — low debt load (0.01)
Interest Cover
N/A
Data not available

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Valuation

P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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