Prime Medicine

PRME

Biotechnology · Healthcare

Price

$3.13

-0.09 (-2.80%)

Market Cap

$565.3M

Exchange

NASDAQ

Winston Score

Winston is worried

Weak fundamentals across most pillars.

Based on the IPO prospectus (annual filing). This score will refine automatically once the company reports its first quarters.

Share count rising — dilution

+55.4% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 95.7M (2021) → 148.8M (2025)

Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address diseases by deploying gene editing technology. It offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transcriptase enzyme; and a pegRNA, which targets the Prime Editor to a specific genomic location and provides a template for making the desired edit to the target DNA sequence. The company was incorporated in 2019 and is headquartered in Cambridge, Massachus

Winston Score History

Growth Profile

For growth stock investors

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-100.0% YoY

YoY Growth Rate

Revenue declining

EPS Growth

+29.4% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$161M/ year

→ Flat (+3% vs prior year)

>1,000% of revenue

192.7x the sector average (18%)

Steady R&D investment year-over-year

Insider Activity

67.2%ownership

→ Flat

Insiders holding steady — not selling despite ability to

Cash Runway

~4 months

$64M cash & investments

Quarterly Free Cash Flow

→ Burn rate stable

Short runway — potential dilution ahead through share issuance

Cash watch

Prime Medicine has less than a year of cash at its current burn rate. Growth investors should watch for potential share dilution from future fundraising — that directly reduces your ownership.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Gross Margin

-58.1%

Thin — -58.1% gross margin

Operating Margin

-4498.1%

Losing money on operations — -4498.1%

ROCE

-90.9%

Weak — -90.9% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales YoY

+55.3%

Fast-growing sales (55.3% YoY)

EPS YoY

N/A

—

Data not available

EPS Consistency

N/A

Data not available

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Cash Flow

Cash Conversion

N/A

—

Data not available

FCF Margin

-3607.4%

Burning cash (-3607.4%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity

0.90

Moderate — manageable debt (0.90)

Interest Cover

N/A

—

Data not available

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Valuation

P/E Ratio (TTM)

N/M

—

Negative earnings — P/E not meaningful

P/E vs Forward

N/A

not available

Data not available

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Dividends

Not applicable for this business.

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