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ProKidney

PROK
26
Biotechnology · Healthcare
Price
$1.62
+0.01 (+0.62%)
Market Cap
$544.7M
Exchange
NASDAQ
Winston Score
26
Winston is worried
Below-average fundamentals — multiple weak pillars.

Share count rising — dilution

+320.0% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 31.9M (2021) → 133.9M (2025)

ProKidney is a clinical-stage biotechnology company focused on treating chronic kidney disease (CKD). Its main product is REACT (Renal Autologous Cell Therapy), a cell therapy that uses a patient's own kidney cells to try to slow the progression of kidney disease. The target patients are adults with CKD, a condition affecting hundreds of millions of people worldwide with very few treatment options beyond dialysis or transplant.

The company does not yet generate meaningful revenue, as REACT is still in clinical trials and has not received regulatory approval. ProKidney is based in the United States and is a small, early-stage company funded primarily through equity raises rather than product sales. Its potential moat lies in its proprietary cell therapy approach, but the biggest risk is clinical and regulatory — if REACT fails to show sufficient effectiveness or safety in late-stage trials, the company has no approved product to fall back on.

Winston Score History

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-1.7% YoY

YoY Growth Rate

Revenue declining

EPS Growth

-7.7% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$114M/ year

Declining (-11% vs prior year)

>1,000% of revenue

710.0x the sector average (18%)

R&D spend declining — could signal cost-cutting or efficiency

Insider Activity

26.6%ownership

Flat

Insiders holding steady — not selling despite ability to

Cash Runway

~7 months

$102M cash & investments

Quarterly Free Cash Flow

→ Burn rate stable

Short runway — potential dilution ahead through share issuance

Cash watch

ProKidney has less than a year of cash at its current burn rate. Growth investors should watch for potential share dilution from future fundraising — that directly reduces your ownership.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Gross Margin
0.0%
Thin — 0.0% gross margin
Operating Margin
0.0%
Thin — 0.0% operating margin
ROCE
0.0%
Weak — 0.0% return on capital

ROIC between 0% and 5%. They earn a few cents back per dollar invested in the business.

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Growth

Sales YoY
+190.5%
Fast-growing sales (190.5% YoY)
EPS YoY
N/A
Data not available
EPS Consistency
0/8 quarters
Earnings rarely grow — volatile business

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Cash Flow

Cash Conversion
N/A
Data not available
FCF Margin
-16453.3%
Burning cash (-16453.3%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity
0.01
Conservative — low debt load (0.01)
Interest Cover
N/A
Data not available

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Valuation

P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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