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Protalix BioTherapeutics

PLX
76
Biotechnology · Healthcare
Price
$2.38
+0.07 (+3.03%)
Market Cap
$191.8M
Exchange
New York Stock Exchange Arca
Winston Score
76
Winston is happy
A high-quality business with solid fundamentals.

Share count rising — dilution

+77.9% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 44.1M (2021) → 78.5M (2025)

Protalix BioTherapeutics is a small biotech company that makes medicines for rare genetic diseases. Its main product is taliglucerase alfa (sold as Elelyso), a treatment for Gaucher disease — a condition where the body cannot break down certain fatty substances properly. The company uses a unique plant-based manufacturing system, growing its drug proteins in carrot cells instead of the more common mammalian cell systems used by larger rivals.

Protalix earns money by selling Elelyso through a partnership with Pfizer, which handles commercial distribution in most markets outside of Israel and Brazil. The company also has a second approved drug, pegunigalsidase alfa (Elfabrio), for Fabry disease, developed with Chiesi Farmaceutici. Operating in a niche rare-disease space gives Protalix some pricing power, but its small size and dependence on a limited number of drugs create meaningful concentration risk. The key growth driver is expanding Elfabrio's market share in Fabry disease, where it competes against established treatments from larger companies.

Winston Score History

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+233.7% YoY

YoY Growth Rate

Revenue accelerating

EPS Growth

+587.3% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$19M/ year

Rising (+47% vs prior year)

36.1% of revenue

2.0x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

3.9%ownership

Relatively low insider ownership

Cash Position

Cash flow positive

$52M cash & investments

Quarterly Free Cash Flow

↑ Burn rate improving

Company generates more cash than it spends — no dilution risk from fundraising

Revenue accelerating

Protalix BioTherapeutics grew revenue 234% year-over-year and the growth rate is speeding up. That's the kind of momentum growth investors look for — the question is whether margins can follow.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Gross Margin
87.8%
Premium pricing power — 87.8% gross margin
Operating Margin
62.7%
Excellent — 62.7% operating margin
ROCE
30.8%
Exceptional — 30.8% return on capital

ROIC above 25%. Every dollar invested in the business earns more than 25 cents back per year.

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Growth

Sales YoY
+27.8%
Fast-growing sales (27.8% YoY)
EPS YoY
+246.1%
Earnings growing fast (246.1% YoY)

Earnings growing 25%+ a year. The compounder zone.

EPS Consistency
4/8 quarters
Earnings inconsistent quarter-to-quarter

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Cash Flow

Cash Conversion
98%
Turns 98% of profit into real cash
FCF Margin
17.0%
Converts sales into free cash efficiently (17.0%)

FCF margin between 10% and 20%. Every $100 in sales becomes $10 to $20 in real cash.

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Stability

Debt / Equity
0.02
Conservative — low debt load (0.02)
Interest Cover
12.86x
Comfortably covers interest (12.9x)

Interest coverage above 8. Profits cover interest many times over.

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Valuation

P/E Ratio (TTM)
12.3x
Attractive valuation — P/E 12.3

P/E in the normal range. Price is roughly $15 for every $1 of yearly profit.

P/E vs Forward
+0.5
GROWING
Earnings roughly flat

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Dividends

Not applicable for this business.
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