Ultragenyx Pharmaceutical

RARE

Biotechnology · Healthcare

Price

$29.28

-0.94 (-3.11%)

Market Cap

$2.88B

Exchange

NASDAQ

Winston Score

Winston is worried

Weak fundamentals across most pillars.

Share count rising — dilution

+45.4% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 67.8M (2021) → 98.6M (2025)

Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare genetic diseases in North America, Europe, and internationally. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the

Winston Score History

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Growth Profile

For growth stock investors

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

-2.4% YoY

YoY Growth Rate

Revenue declining

EPS Growth

-17.2% YoY

YoY Growth Rate

Earnings declining

R&D Spend

$750M/ year

↑ Rising (+7% vs prior year)

111.4% of revenue

6.2x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

4.0%ownership

→ Flat

Insiders holding steady — not selling despite ability to

Cash Runway

~3 months

$175M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Short runway — potential dilution ahead through share issuance

Heavy R&D investment

Ultragenyx Pharmaceutical is putting 111% of revenue into R&D and that number is rising. That's 6.2x the sector average.

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

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Quality

Gross Margin

77.9%

Premium pricing power — 77.9% gross margin

Operating Margin

-124.3%

Losing money on operations — -124.3%

ROCE

-17.5%

Weak — -17.5% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales YoY

+13.3%

Fast-growing sales (13.3% YoY)

EPS YoY

N/A

—

Data not available

EPS Consistency

0/8 quarters

Earnings rarely grow — volatile business

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Cash Flow

Cash Conversion

N/A

—

Data not available

FCF Margin

-76.5%

Burning cash (-76.5%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity

N/A

Data not available

Interest Cover

N/A

Data not available

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Valuation

P/E Ratio (TTM)

N/M

—

Negative earnings — P/E not meaningful

P/E vs Forward

N/A

not available

Data not available

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Dividends

Not applicable for this business.

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