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Xilio Therapeutics

XLO
34
Biotechnology · Healthcare
Price
$8.88
-0.15 (-1.66%)
Market Cap
$58.4M
Exchange
NASDAQ Global Select
Winston Score
34
Winston is serious
Below-average fundamentals — multiple weak pillars.

Share count rising — dilution

+20774.3% over 4y

The company has issued more shares over this period, which dilutes each existing shareholder’s stake.

Diluted shares outstanding: 400K (2021) → 83.6M (2025)

Xilio Therapeutics is a small biotechnology company focused on developing cancer treatments. It works on a type of drug called "tumor-selective" immunotherapies, which are designed to activate the immune system specifically inside tumors rather than throughout the whole body. The goal is to make cancer-fighting drugs more effective while reducing the harmful side effects that come with traditional immunotherapy.

Xilio makes no product revenue yet and funds its research through investor capital and potential partnership deals. The company operates primarily in the United States and, with a market cap of around $100 million, is considered a clinical-stage biotech, meaning its drugs are still being tested in human trials. Its approach of targeting immune activity directly within tumors could be a differentiator if clinical results prove strong, but the biggest risk is that its drug candidates could fail in trials, which would severely threaten the company's future given its ongoing cash burn and negative operating margins.

Winston Score History

Growth Profile

When traditional metrics don't capture the full picture, these are the signals growth stock investors use instead.

Revenue Growth

+331.7% YoY

YoY Growth Rate

Strong revenue growth

EPS Growth

+77.0% YoY

YoY Growth Rate

EPS growth accelerating

R&D Spend

$56M/ year

Rising (+36% vs prior year)

128.0% of revenue

7.1x the sector average (18%)

Investing heavily in future products and technology

Insider Activity

64.2%ownership

Insiders own a meaningful stake in the company

Cash Runway

~20 months

$150M cash & investments

Quarterly Free Cash Flow

↓ Burn rate worsening

Adequate runway but may need to raise capital within 2 years

Strong grower

Xilio Therapeutics is growing revenue at 332% year-over-year. The Winston Score penalises unprofitable companies, but revenue at this pace tells a different story — this is a company still in "build mode."

The Winston Score above measures business quality today. Growth stocks often score lower because they invest in the future rather than maximising current profits. These metrics show what matters most for evaluating that future.

Score breakdown

Every number that matters to educated investors.

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Quality

Gross Margin
97.3%
Premium pricing power — 97.3% gross margin
Operating Margin
-111.6%
Losing money on operations — -111.6%
ROCE
-18.1%
Weak — -18.1% return on capital

Negative ROIC means the business is losing money on every dollar invested in it.

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Growth

Sales YoY
+476.7%
Fast-growing sales (476.7% YoY)
EPS YoY
N/A
Data not available
EPS Consistency
2/8 quarters
Earnings rarely grow — volatile business

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Cash Flow

Cash Conversion
N/A
Data not available
FCF Margin
-107.3%
Burning cash (-107.3%)

Free cash flow is negative. They are burning cash, not generating it.

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Stability

Debt / Equity
0.07
Conservative — low debt load (0.07)
Interest Cover
N/A
Data not available

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Valuation

P/E Ratio (TTM)
N/M
Negative earnings — P/E not meaningful
P/E vs Forward
N/A
not available
Data not available

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Dividends

Not applicable for this business.
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